Adrafinil Dosage Guide | Uses, Indications, and Microdosing

Curious about the correct Adrafinil dosage you should be taking?

If so, you’ve come to just the right place.

Many people are interested in taking Adrafinil, but aren’t sure about the recommended dosage guidelines.

P.S: This is the best place to buy Adrafinil online.

That’s why we created this guide to explain everything you need to know before you get started. We’ll tell you the recommended doses, the side effects you can expect, and the best dosage schedule — that will give you maximum benefits without building up any tolerance.

This is not medical or legal advice. This guide is strictly for entertainment purposes only. Always consult a medical professional before consuming any nootropic and always abide by the laws of your country. Please read my disclaimer page, too.

What is Adrafinil?

Adrafinil is a ‘eugeroic’, or ‘wakefulness-promoting’ agent, that was discovered in 1974 by two French chemists. It was developed by Lafon (now Cephalon) and introduced to the French market under the brand name ‘Olmifon’ in 1985.

Olmifon was widely prescribed to narcolepsy sufferers to prevent them from falling asleep at inconvenient times [1]. Cephalon discontinued Olmifon in France in 2011, but several companies continue to produce and market generic versions of Adrafinil around the world.

These generic versions serve no medical or pharmaceutical benefits these days.

Currently, Adrafinil is a popular nootropic or smart drug. Individuals take the supplement to improve cognition and increase focus.

Best Nootropics Adrafinil

Adrafinil Benefits

Adrafinil’s main benefit is that it promotes wakefulness. Early pharmacological studies revealed it to have psychostimulant-like effects in animals, and it later underwent human trials as a narcolepsy treatment.

Adrafinil is a ‘prodrug’, meaning that it is metabolized (or converted) in the liver into the pharmacologically active drug Modafinil [2].

Modafinil is Adrafinil’s active metabolite so the two substances have virtually identical pharmacological effects.

Adrafinil is commonly used ‘off-label’ by individuals who want to avoid fatigue or need to stay awake for long periods.

These include:

  • People who need to be awake and alert for extended amounts of time, such as truck drivers, medical staff, and military aviators [3].
  • People in high power jobs who frequently work long hours.
  • People engaged in challenging mental activities, such as students preparing for exams, professors, academics, and researchers.

Adrafinil is considered to be a ‘nootropic’; a term coined by Dr. Corneliu Giurgea in 1972 to describe any substance that can enhance a cognitive function like memory, concentration, focus, or information processing, while also protecting the mind from stress [4].

A 300-600mg dose of Adrafinil offers the following benefits [5]:

  • 8+ hours of extreme concentration.
  • Increased attention span.
  • Supercharged motivation.
  • Enhanced alertness [6].
  • Improved working memory [7].
  • Reduced sense of fatigue.

Adrafinil is a long-lasting stimulant and cognitive enhancer, with a peak effect duration of eight hours. It works by ramping up histamine levels in the brain, leading to a feeling of alertness [8]. Adrafinil suppresses appetite and prevents you from feeling fatigued, letting you work up to eight hours straight without taking a break [9].

Adrafinil is considered a ‘smart drug’ because it improves working and episodic memory [10]. It binds to the brain’s dopamine transporter and prevents the reuptake of dopamine [11]. With more dopamine, serotonin, and norepinephrine in your brain, you can work, study, and remember things much more effectively.

One of Adrafinil’s biggest benefits is its ability to reduce reactivity to fear stimuli in the brain region involved in anxiety, the amygdala [12]. Even if you’re panicked about meeting a tight deadline, or nervous about an upcoming exam, Adrafinil lets you work efficiently and prevents fear or nerves from clouding your judgment.

The period of improved cognition from Adrainfil can last up to 24 hours, with some residual benefits reported up to 60 hours later.

Adrafinil Side Effects and Safety

There’s nothing we love better than being able to get a huge boost in productivity and creativity, no matter where we are in the world.

Adrafinil is the ideal nootropic, as it is 100% legal almost everywhere. However, it does come with some side effects that you should know about.

Firstly, it has not been approved by the U.S. Food and Drug Administration and so none of the statements you may read about products containing Adrafinil will have been evaluated by the FDA. Adrafinil is sold as a ‘dietary supplement’ meaning that it isn’t intended to diagnose, treat, cure, or prevent any disease.

What we do know is that Adrafinil is metabolized by the liver into Modafinil. Its action is less specific than Modafinil and it produces several side effects that Modafinil does not, such as skin irritation and elevated liver enzymes, especially with prolonged use [13].

Adrafinil can interact with hormonal birth control medications and shouldn’t be taken during pregnancy or while breastfeeding.

Adrafinil has also been linked to orofacial dyskinesia, which is where the mouth and face move involuntarily in repetitive ways [14].

There are no scientific studies into Adrafinil’s side effects when taken ‘off-prescription’ as a nootropic. However, one study looked at what happened when people who had been incorrectly diagnosed with narcolepsy, i.e. non-sufferers, were given a 200mg dose of Modafinil, Adrafinil’s active metabolite.

The reported Adrafinil side effects include [15]:

  • Headaches
  • Dehydration
  • Stomach pain
  • Nausea
  • Anxiety
  • Insomnia
  • Lumbago
  • Diarrhea
  • Dyspepsia
  • Rhinitis
  • Vertigo
  • Dry mouth
  • Back pain

The study noted that these side effects were mild and subsided within 24 hours. This list provides a useful point of reference for what to expect when you take an equivalent dose of Adrafinil.

Wondering what an equivalent dose would be?

A 300mg dose of Adrafinil is roughly equivalent to 100mg of Modafinil, so a dose of 300-600mg of Adrafinil would approximate 200mg of Modafinil.

In our experience, the majority of Adrafinil’s side effects can be mitigated or minimized by taking the following precautions:

  • Stay well hydrated: Headaches, dehydration, dry mouth, and nausea are usually caused by dehydration. You can avoid these side effects by staying well hydrated throughout the day.
  • Consume in the morning: Adrafinil is best consumed in the morning to avoid sleep disruption and insomnia caused by increased wakefulness. If you take the dose early in the morning, the effect should have faded by the evening.
  • Lower the dose: If you get bad side effects, you can lower your dose from say 300mg to 200mg, or until you find an amount you can tolerate. We’ll discuss microdosing in more detail later in this guide.

Adrafinil has no structural relationship to any substances known to induce addiction and is not a precursor molecule for substances that have the potential for misuse.

However, Adrafinil’s active metabolite, Modafinil, has been shown to function as a reinforcer and have abuse potential under certain circumstances, especially when taken at a high dosage.

In one case, a man with bipolar affective disorder developed Modafinil dependence and later on, had hypersexuality, when he increased his dose of Modafinil from 400 to 1,000 mg/day [16]. Given that an equivalent dose of Adrafinil would be four to ten 300mg capsules, this level of consumption is extreme.

Overall, Adrafinil is pretty safe when taken at the recommended dosage (1-2 capsules per day) and shouldn’t give you any serious issues.

But again, we aren’t doctors and this isn’t medical advice, so if you are in any doubt about how Adrafinil may interact with your existing medications, contact your doctor as soon as possible.

Adrafinil Tablets

Adrafinil Dosage Guidelines | What You MUST Know

When taking Adrafinil as a nootropic, finding the right dosage is important.

As Adrafinil isn’t intended to be consumed as a nootropic, you won’t find any guidance in conventional medical literature or peer-reviewed medical journals about its ‘off-prescription’ use. Adrafinil is unregistered and unlicensed in almost every country except Australia and has never been approved for use as a nootropic or prescribed as such.

However, we do know that Adrafinil’s active metabolite, Modafinil, is well tolerated in dosages between 100-200mg per day. And we also know that a 300mg capsule of Adrafinil is equivalent to a 100mg dose of Modafinil.

Therefore, the recommended Adrafinil dose is between 300-600mg per day, or 1 – 2 300mg capsules.

From medical literature, we know that:

  • Adrafinil should be taken orally on an empty stomach.
  • Its effects usually become apparent within 45–60 minutes.
  • Adrafinil has an elimination half-life of one hour, and its peak effect duration is around eight hours.
  • Dosages should be taken early in the morning to avoid side effects like sleeplessness and insomnia.

New users should be especially vigilant when taking Adrafinil and may start with 150mg (half a capsule) per day in order to gauge their body’s response.

A particular concern with Adrafinil is building tolerance and needing to consume increasingly more to attain the same effect. That’s why it is recommended to take Adrafinil every other day, up to a maximum of four times per week. After two weeks of use, a one week break should be taken.

Addiction is not a particular concern with Adrafinil. It’s not a precursor molecule for addictive substances and it doesn’t have any structural relationship to substances known to induce addiction, so it won’t cause dependency issues.

Adrafinil Microdosing?

If you decide to take Adrafinil or any nootropic, you should be cautious about the side effects and start with the lowest possible dose.

The practice of taking a very low dose of Adrafinil, 150mg, or half a capsule, is known as microdosing. You can start with this dose and see how your body responds. If you tolerate the dose well, you can ramp up until you reach the desired effects.

Adrafinil vs. Modafinil

As Adradinil is the parent drug of Modafinil, both substances have almost identical pharmacological effects. However, there are several key differences between the two.

The first key difference is that Adrafinil’s effects take longer to become apparent than Modafinil as it takes time to be metabolized in the liver.

Secondly, medical studies have indicated that Modafinil is much more potent than its parent drug, Adrafinil. As it doesn’t need to be metabolized in the liver, Modafinil’s action is faster and more specific. This means that you can expect less stomach pain, skin irritation, anxiety, and lower liver enzymes when you take Modafinil, compared with Adrafinil.

Modafinil is utilized by the body quicker and more effectively, so much smaller doses are required. That’s why one 200mg Modafinil tablet is equivalent to taking two 300mg Adrafinil tablets.

A key difference between Adrafinil and Modafinil is that Modafinil is a prescription medication in most countries whereas Adrafinil is 100% legal.

The only two countries that restrict Adrafinil’s sale and use are Australia, where it is an S4 prescription only medication, and the US where it is unscheduled and not FDA approved.

In terms of cost, both Adrafinil and Modafinil cost exactly the same when you factor in the dosage size. A bottle of sixty 300mg Adrafinil capsules costs the same amount as 30 Modalert (generic Modafinil) 200mg tablets: $69.

Overall, both Modafinil and Adrafinil offer solid cognitive benefits. Modafinil is stronger and more powerful, but Adrafinil can be purchased over-the-counter in most countries — whereas Modafinil cannot.

adrafinil vs modafinil

Where to Buy Adrafinil Online | 2020 Guide

As Adrafinil is currently unscheduled and unregulated in most countries, it is 100% legal to buy without a prescription. Unfortunately, you can’t just head down to your local pharmacy or supplement store and pick some up.

So, where should you buy Adrafinil in 2020?

The best way to order Adrafinil is through a reputable online vendor. We’ve reviewed the top suppliers and have found AbsorbYourHealth to be the most reliable and efficient nootropics supplier.

These guys are highly reputable and have built a solid track record for shipping quality smart drugs since they entered the scene in 2011.

Some reasons why we rate them as the #1 Adrafinil vendor around are;

  • Rigorous 3rd Party Testing: AbsorbYourHealth gets every batch of Adrafinil they sell tested by independent laboratories to verify its authenticity and purity. They only ship the highest quality nootropics so you can order with confidence.
  • International Shipping to over 100 countries: All U.S. orders over $70 and all international orders over $200 qualify for free shipping. Orders are shipped within 2-3 business days and come with free tracking.
  • Fair returns policies: US customers have 90 days to return their product for a full refund if they aren’t entirely satisfied with their orders. If there is an issue with USPS, they can ask for a full refund or free reshipping in the highly unlikely event that an order does get through.

Overall, this is the best Adrafinil vendor we’ve found…

Adrafinil Dosing | Verdict

If you wanted to learn the recommended Adrafinil dosage guidelines, then hopefully this guide answered all your questions!

We’ve given you a complete overview of how to use Adrafinil, the optimal doses to take, which side effects to watch out for, and everything in between.

P.S. Click here to order your Adrafinil today!


  1. Milgram, N.W., Callahan, H. and Siwak, C. (1999), Adrafinil: A Novel Vigilance Promoting Agent. CNS Drug Reviews, 5: 193-212. doi:10.1111/j.1527-3458.1999.tb00100.x
  2. Murillo-Rodríguez E, Barciela Veras A, Barbosa Rocha N, Budde H, Machado S. An Overview of the Clinical Uses, Pharmacology, and Safety of Modafinil. ACS Chem Neurosci. 2018;9(2):151-158. doi:10.1021/acschemneuro.7b00374
  3. Ooi T, Wong SH, See B. Modafinil as a Stimulant for Military Aviators. Aerosp Med Hum Perform. 2019;90(5):480-483. doi:10.3357/AMHP.5298.2019
  4. Giurgea C. Vers une pharmacologie de l’activité intégrative du cerveau. Tentative du concept nootrope en psychopharmacologie [Pharmacology of integrative activity of the brain. Attempt at nootropic concept in psychopharmacology]. Actual Pharmacol (Paris). 1972;25:115-156.
  5. Siwak CT, Callahan H, Milgram NW. Adrafinil: effects on behavior and cognition in aged canines. Prog Neuropsychopharmacol Biol Psychiatry. 2000;24(5):709-726. doi:10.1016/s0278-5846(00)00103-2
  6. Brühl AB, d’Angelo C, Sahakian BJ. Neuroethical issues in cognitive enhancement: Modafinil as the example of a workplace drug?. Brain Neurosci Adv. 2019;3:2398212818816018. Published 2019 Feb 15. doi:10.1177/2398212818816018
  7. Battleday RM, Brem AK. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review. Eur Neuropsychopharmacol. 2015;25(11):1865-1881. doi:10.1016/j.euroneuro.2015.07.028
  8. Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A. Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett. 2003;339(2):143-146. doi:10.1016/s0304-3940(03)00006-5
  9. Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001;63(6):637-672. doi:10.1016/s0301-0082(00)00039-3
  10. Zolkowska D, Jain R, Rothman RB, et al. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther. 2009;329(2):738-746. doi:10.1124/jpet.108.146142
  11. Rasetti, R., Mattay, V. S., Stankevich, B., Skjei, K., Blasi, G., Sambataro, F., Arrillaga-Romany, I. C., Goldberg, T. E., Callicott, J. H., Apud, J. A., & Weinberger, D. R. (2010). Modulatory effects of modafinil on neural circuits regulating emotion and cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2101–2109.
  12. Minzenberg MJ, Carter CS. Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology. 2008;33(7):1477-1502. doi:10.1038/sj.npp.1301534
  13. Ballas CA, Kim D, Baldassano CF, Hoeh N. Modafinil: past, present and future. Expert Rev Neurother. 2002;2(4):449-457. doi:10.1586/14737175.2.4.449
  14. Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Adrafinil-induced orofacial dyskinesia. Mov Disord. 2004;19(8):965-966. doi:10.1002/mds.20154
  15. Lopes E, Pereira D, da Silva Behrens NS, et al. Cataplexy as a side effect of modafinil in a patient without narcolepsy. Sleep Sci. 2014;7(1):47-49. doi:10.1016/j.slsci.2014.07.015
  16. Swapnajeet S, Bn S, Gourav G. Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence. Clin Psychopharmacol Neurosci. 2016;14(4):402-404. doi:10.9758/cpn.2016.14.4.402


After utilizing nootropics for the better part of a decade, I realized the potent results these products produce -- with regards to productivity and cognitive enhancement. Soon thereafter, I became obsessed with finding the premier smart drugs on the market. Then using them to improve my life. When I'm not devouring everything I can about nootropics and the science behind why they work, you'll find me traveling around the world or in the gym.

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