Phenibut Half-Life | The #1 A-Z Guide

Wondering how long the Phenibut half-life is? You’re in the right spot.

Phenibut is one of the best nootropics available on the market, especially for creatives. Phenibut users around the world report that it creates a feeling of euphoria, reduces anxiety, makes it easy to socialize, improves sleep, and even boosts mood. Sounds a bit like magic, doesn’t it?

P.S: Click here to order Phenibut from the world’s best vendor!

You can be a university student writing a really important paper or a professional trying to come up with new ways to market your product and, in both cases, you’ll love the creativity this nootropic sparks.

But maybe you’re wondering about how it works.

When does Phenibut peak? How long does Phenibut stay in your system? What you should expect? How long does Phenibut last?

This is not medical or legal advice. This guide is strictly for entertainment purposes only. Always consult a medical professional before consuming any nootropic and always abide by the laws of your country. Please read my disclaimer page, too.

What is Phenibut?

Before you understand how Phenibut breaks down, you should first understand a bit about what it is.

Phenibut—also known as pbut, noofen, and party powder—is a central nervous system tranquilizer developed in the 1960s in Russia. It was originally developed as a treatment for insomnia and anxiety. It is a psychotropic drug, which means that it can temporarily alter your perception, mood, behavior, and consciousness [1]. This is how it improves your cognitive function and your mood.

Phenibut is a synthetic form of GABA (gamma-aminobutyric acid), which is an amino acid and one of the most important neurotransmitters that we produce naturally in our bodies. GABA is responsible for reducing nerve excitability—it creates calm and relaxation. GABA regulates and reduces brain agitation by inhibiting excessive neuron firing [1].

Phenibut effects

Characterized as a GABA analog, Phenibut activates the same receptors that GABA does, and so it also has a calming effect on the brain. This is how it has several of its most important benefits: deeper sleep, reduced stress and anxiety, and less social inhibition [1].

Since it is so effective, Phenibut is used as a prescription tranquilizer in several countries. It’s used to treat conditions like anxiety, depression, alcoholism, nausea, and even stuttering [1].

Because it’s so effective, people are using it as a supplement or recreationally. Recreational users of Phenibut don’t usually use it to treat a specific condition—they use it to live a lighter, less stressful life. People take it for parties because it’s great for socializing, gives you a great feeling of euphoria, and takes away social anxiety [2].

Phenibut is legal

Phenibut Side Effects and Safety

So Phenibut is effective, cheap, and easy to get. With all these benefits, you’re probably wondering if it’s safe… and what the potential side effects are.

First, yes, Phenibut is safe—otherwise, it would not have been used as a medication for almost 40 years in so many countries. But, like any drug, it also has rare and occasional side effects. And, prolonged use of high doses of Phenibut may trigger dependence [3]. It also has some interaction effects, which means you shouldn’t mix it with certain substances.

We already have a whole article on Phenibut side effects, but here’s the shortened version.

Some users report gastrointestinal side effects. These include:

  • Vomiting
  • Nausea
  • Diarrhea

Although rare, some users report symptoms linked to the central nervous system. These include:

  • Insomnia
  • Depression
  • Confusion

To avoid potential side effects, limit how much you take. Start your Phenibut dosing small, and build up after you know how your body reacts to it. Also, to avoid interactions, don’t mix it with [4]:

  • Alcohol
  • Benzodiazepines
  • Anticonvulsant medications
  • Opioids
  • Anti-psychotics
  • Sedatives

Phenibut Half-Life

Here we are. The meat and potatoes of this guide.

You want to know what the half-life of Phenibut is and how long will its effects last. Let’s dig in…

What is the Phenibut half-life?

A substance’s half-life is the average time it takes for the concentration of a substance to be reduced by half in the body.

The Phenibut half-life is about 5.3 hours, according to clinical studies conducted in Russia [5]. That means that it takes about 5.3 hours for a dose of 500 mg to be reduced to 250 mg. After another 5 hours, it’ll be reduced to 125 mg. Then about 62 mg. And so on.

Keep in mind that there are a number of factors that affect the half-life of Phenibut, so it could be a bit less or a bit more for you. These factors include things like:

  • Age
  • Metabolism
  • Weight

What is the Phenibut high and when does it start?

The effects of Phenibut can take an hour or more to begin to be felt in the body.

For me, it’s usually between one and two hours after taking it. This might confuse new users, who might think that the first dose did not work… you might think you should up the dose. It’s better to stick it out and wait for the two hours. Don’t forget that higher Phenibut dosing can lead to a greater chance of side effects. It’s better to start with lighter doses.

Once the effects start, you’ll notice a heightened sense of well-being (which is partly a consequence of reduced anxiety levels), relaxation, and an increase in your sociability. This means that if you’re a bit introverted and ingest Phenibut, chances are that you will become more sociable and ready to chat at parties

Higher doses can result in additional effects, like pain relief and more restful sleep. Studies also show an increase in learning abilities and an improvement in memory, as well as a progressive improvement in reducing stress levels [1, 6, 7, 8].

When is the Phenibut peak and how long does it last?

This is one of the most common questions: how long does the Phenibut peak last?

In practical terms, a Phenibut half-life of about 5.3 hours means that the “Phenibut high” usually lasts for about 4 to 5 hours after it kicks in [5].

So, if you take it at 7:00 pm, you’ll start feeling it between 8:00 and 9:00 pm, and the high will last until about 2:00 am.

While the “high” feeling decreases at about the 5 hours mark, there continue to be some benefits from Phenibut for many hours after. This is kind of like an afterglow effect. Even 24 hours after taking a dose of about 750 mg, you can often reap the benefits of less anxiety and better sleep [5].

How long does Phenibut stay in your system?

The main factor influencing the length of time that Phenibut remains in the body is the dosage that you took, as well as the individual tolerance of each person [6].

That means that age, metabolism, weight, etc., can all influence the time it will take for Phenibut to completely leave your body [9]. For example, older people who consume higher doses of Phenibut tend to excrete it more slowly than people who are younger.

Do the effects continue to be intense for a long time?

Although the effects of Phenibut are long-lasting, with Phenibut you remain perfectly conscious and are able to think clearly. The Phenibut high is not like other drugs.

Of course, as with any other medication or drug, the greater the dosage, the greater the effects, and the longer they last.

Again, you have to keep in mind that, depending on a bunch of factors like your age, size, metabolism, etc., the effects can be more or less intense. That’s why it’s worth having a relatively low Phenibut dosage the first time so you can see how it affects your body. That’ll let you be able to judge how you do your Phenibut dosing going forward.


Where to Buy Phenibut Online | 2020 Guide

You can buy Phenibut legally on several websites — except if you are in Hungary, Australia, Italy, or Lithuania, where the drug has been banned.

Although Phenibut is not approved for medical use in North America or Europe, it is widely used as a dietary supplement and it’s available online.

One thing: make sure that you buy it only from legitimate websites so that you avoid falling for scams.

We recommend: LiftMode. They’ve been really good to me and we’ve never had a problem with them. They ensure that what they sell you is pure and they help you out if there’s ever a problem with your order. They’ve also got great prices.

Half-Life of Phenibut | Verdict

The half-life of Phenibut is 5.3 hours. You can usually feel the effects starting at about 1 to 2 hours after taking it until up to 24 hours after the first dose. But the timing varies according to individual factors such as metabolism, hydration, age, weight, and so on.

Having such a long-lasting effect can be great if you want to improve the quality of your sleep, mood, concentration, get less anxious in social situations, and get a great sleep [10].

Give it a shot!

Click here to order from our favorite vendor!


  1. Lapin I. (2001). Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS drug reviews, 7(4), 471–481. doi:10.1111/j.1527-3458.2001.tb00211.x
  2. Cheung, J. & Penn, J. (2018). Weekly dose: Phenibut. The Conversation.
  3. Koob, G. F. (1996). Drug addiction: the yin and yang of hedonic homeostasis. Neuron, 16(5), 893-896.
  4. Ozon Pharm (n.d.), Fenibut (PDF). [In Russian].
  5. Owen, D. R., Wood, D. M., Archer, J. R., & Dargan, P. I. (2016). Phenibut (4‐amino‐3‐phenyl‐butyric acid): Availability, prevalence of use, desired effects and acute toxicity. Drug and alcohol review, 35(5), 591-596.
  6. Chutko, L. S., Surushkina, S. I., Iakovenko, E. A., Nikishena, I. S., Anisimova, T. I., & Bondarchuk, I. L. (2014). Cognitive and emotional impairments in patients with protracted anxiety-phobic disorders. Therapeutic archive, 86(12), 61-65.
  7. Zyablitseva, E. A., Kositsyn, N. S., & Shul’gina, G. I. (2009). The Effects of Agonists of Ionotropic GABA A and Metabotropic GABA B Receptors on Learning. The Spanish Journal of Psychology, 12(1), 12-20.
  8. Tyurenkov, I. N., Borodkina, L. E., Bagmetova, V. V., Berestovitskaya, V. M., & Vasil’eva, O. S. (2016). Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid. Bulletin of experimental biology and medicine, 160(4), 465-469.
  9. Zheng, K. H., Khan, A., & Espiridion, E. D. (2019). Phenibut Addiction in a Patient with Substance Use Disorder. Cureus, 11(7).
  10. Ahuja, T., Mgbako, O., Katzman, C., & Grossman, A. (2018). Phenibut (β-phenyl-γ-aminobutyric acid) dependence and management of withdrawal: Emerging nootropics of abuse. Case reports in psychiatry, 2018.


After utilizing nootropics for the better part of a decade, I realized the potent results these products produce -- with regards to productivity and cognitive enhancement. Soon thereafter, I became obsessed with finding the premier smart drugs on the market. Then using them to improve my life. When I'm not devouring everything I can about nootropics and the science behind why they work, you'll find me traveling around the world or in the gym.

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